TMEM106B C-Terminal fragment aggregation exacerbates α-synuclein and TDP-43 proteinopathy phenotypes.
Ruben Riordan, Aileen Saxton, Marina Han, Kailee Parrot, Brian C. Kraemer
This study shows TMEM106B C-terminal fragment aggregation synergizes with α-synuclein and TDP-43 to worsen neurodegeneration in C. elegans, but not with tau.
bioRxiv · Oct 30, 2026 · PreprintNeuroscience