Author

Ruben Riordan

University of WashingtonORCID 0000-0002-8124-3367Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Approach:experimental assay· 2 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Brian C. KraemeriD· 2 shared Aileen Saxton· 1 shared Aleen D. SaxtoniD· 1 shared Kailee Parrot· 1 shared Marina Han· 1 shared Nicole F. LiachkoiD· 1 shared Pamela J. McMillaniD· 1 shared Rebecca L. KowiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersNeuroscience

Brian C. KraemerORCID

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2 papers

Recent·Most cited

TMEM106B C-Terminal fragment aggregation exacerbates α-synuclein and TDP-43 proteinopathy phenotypes.

Ruben Riordan, Aileen Saxton, Marina Han, Kailee Parrot, Brian C. Kraemer

This study shows TMEM106B C-terminal fragment aggregation synergizes with α-synuclein and TDP-43 to worsen neurodegeneration in C. elegans, but not with tau.

bioRxiv · Oct 30, 2026 · PreprintNeuroscience

TMEM106B C-terminal fragments aggregate and drive neurodegenerative proteinopathy.

Ruben Riordan, Aleen D. Saxton, Pamela J. McMillan, Rebecca L. Kow, Nicole F. Liachko, Brian C. Kraemer

This study identifies TMEM106B C-terminal fragments as aggregating proteins linked to neurodegenerative diseases and shows their toxic effects in a C. elegans model.

bioRxiv · Jun 11, 2024 · PreprintNeuroscience