A proline-rich-domain-binding single domain antibody selectively inhibits RNA-induced liquid-liquid phase separation of tau
Simon Thiou, Leslie Martin, Evangelia Manousaki, Marine Nguyen, Justine Mortelecque, Leïla Heidsieck, François‐Xavier Cantrelle, David L Blum, Valérie Buée‐Scherrer, Luc Buée, Isabelle Landrieu, Elian Dupré, Clément Danis
The paper uses single-domain antibodies to investigate how different tau domains influence RNA-induced tau liquid-liquid phase separation, identifying a proline-rich domain as critical for condensation.
ACS Chemical Neuroscience · May 8, 2026Peer-reviewedBiochemistry