Valérie Buée‐Scherrer

The paper uses single-domain antibodies to investigate how different tau domains influence RNA-induced tau liquid-liquid phase separation, identifying a proline-rich domain as critical for condensation.

This study identifies and characterizes a novel N-terminally acetylated Tau variant that accumulates in AD models and patients, exacerbates pathology, and is a potential therapeutic target.

This study shows that impairing the AMPK-ULK1 cascade in Alzheimer's disease leads to mitochondrial dysfunction and AD-related changes, which are improved by metformin treatment.