Marion Ziegler

Spatiotemporal analysis of de novo KSHV infection using Crispr/Cas9-based 3D live cell imaging at single episome resolution

This study develops a CRISPR/Cas9-based 3D live cell imaging system to track KSHV episomes in real-time, revealing their spatiotemporal dynamics during infection.

Polycomb group proteins protect latent Kaposi sarcoma-associated herpesvirus from episome clearance and HUSH-dependent chromatin silencing

This study shows that Polycomb group proteins maintain KSHV latency by repressing viral gene expression and protecting episomes from HUSH-dependent silencing.