Author

Martin V. Hamann

Leibniz Institute of Virology (LIV)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Sabrina M. LeddyiD· 3 shared Adam T. GrundhoffiD· 2 shared Maisha AdibaiD· 2 shared Ulrike C. LangeiD· 2 shared Carola Schneider· 1 shared Cédric FeschotteiD· 1 shared Christoph Schwarz· 1 shared Daniel Foth· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMolecular Biology

Sabrina M. LeddyORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Development of a recombinant adeno-associated virus vector for human T lymphocyte- and natural killer cell-targeted gene therapy

Hendrik Jahnz, Martin V. Hamann, H.O. Kim, Yaping Sun, Natalia A. Salazar-Quiroz, Li Zhu, Sabrina M. Leddy, Umm E Swaiba, Carola Schneider, Daniel Foth, Niklas Beschorner, Priti Kumar, Ulrike C. Lange

This paper develops a CD7-targeted rAAV vector for efficient gene delivery to human T and NK cells, showing reduced off-target effects and improved transgene expression through genome optimization.

Human Gene Therapy · Sep 16, 2026Peer-reviewedMolecular Biology

Selective persistence of HIV-1-infected T cell clones can occur through immune reprogramming driven by defective, transcriptionally active proviruses

Martin V. Hamann, Lisa Brauckmann, Christoph Schwarz, Michael Spohn, Ramon Stoeck, Sabrina M. Leddy, Julie Frouard, Maisha Adiba, Riekje Winzer, Sanamjeet Virdi, Adam T. Grundhoff, Cédric Feschotte, Frauke Muecksch, Nadia R. Roan, Eva Tolosa, U. Schiefer Lange

This study shows that defective HIV-1 proviruses can reprogram CD4+ T cells by altering BACH2 and STAT5B gene expression, leading to immune evasion and persistence in ART-treated individuals.

bioRxiv · Sep 22, 2025 · PreprintMicrobiology

Expression of LTR and LINE1 transposable elements defines atypical teratoid/rhabdoid tumor subtypes

Martin V. Hamann, Shweta Godbole, Maisha Adiba, Sabrina M. Leddy, Jelena Navolić, Ghazaleh Tabatabai, Daniel J. Merk, Ulrike C. Lange, Julia E. Neumann

This study identifies distinct TE transcription profiles in ATRT subtypes, revealing unique patterns in ATRT-MYC that may inform new therapeutic strategies.

Acta Neuropathologica Communications · Jul 22, 2025Peer-reviewedCancer Biology

Spatiotemporal analysis of de novo KSHV infection using Crispr/Cas9-based 3D live cell imaging at single episome resolution

Thomas Günther, Simon Weissmann, Martin V. Hamann, Henry Scheibel, Jens B. Bosse, Marion Ziegler, Adam T. Grundhoff

This study develops a CRISPR/Cas9-based 3D live cell imaging system to track KSHV episomes in real-time, revealing their spatiotemporal dynamics during infection.

bioRxiv · Feb 11, 2025 · PreprintMicrobiology