Cardiolipin deficiency disrupts electron transport chain and drives steatohepatitis
Marisa J. Brothwell, Guoshen Cao, J. Alan Maschek, Annelise M. Poss, Alek D. Peterlin, Liping Wang, Talia B. Baker, Justin L. Shahtout, Piyarat Siripoksup, Quentinn Pearce, Jordan M. Johnson, Fabian Finger, Alexandre Prola, Sarah Pellizzari, Gillian Hale, , Katsuhiko Funai
This study shows that mitochondrial cardiolipin deficiency disrupts electron transport chain function, leading to oxidative stress and promoting MASH in mice and humans.
bioRxiv · Oct 10, 2024Biochemistry