Targeting an Olfactory Receptor Mitigates High Residual Platelet Reactivity and Arterial Thrombosis Through Actin Cytoskeleton Depolymerization
Anu Aggarwal, Vara Prasad VN Josyula, Nancy Wang, Moua Yang, Young Jun Shim, Quinn Patrick Kennedy, Reina Samuel, Naseer Sangwan, Suman Guntupalli, Matthew Godwin, Huijun Edelyn Park, Mariya Ali, Courtney Jennings, Bhairavi Rajasekar, Alliefair Scalise, , Scott J. Cameron
The paper identifies OR2L13 agonists that reduce platelet reactivity and thrombosis by depolymerizing the actin cytoskeleton through HSP27 phosphorylation.
Circulation · Apr 7, 2026Peer-reviewedPhysiology