Concealed Conduction Vulnerability in Scn1b Haploinsufficiency Emerges with Osmotic Stress
Rowan O. Maisonneuve, Chandra B. Bain, Clare L. Dennison, Mark D. Warren, Gregory S. Hoeker, Robert G. Gourdie, Steven Poelzing
This study shows that Scn1b haploinsufficiency causes structural changes in cardiac intercalated discs that increase sensitivity to osmotic stress, unmasking concealed conduction abnormalities.
bioRxiv · Jun 19, 2026 · PreprintBiophysics