Steven Poelzing

Concealed Conduction Vulnerability in Scn1b Haploinsufficiency Emerges with Osmotic Stress

This study shows that Scn1b haploinsufficiency causes structural changes in cardiac intercalated discs that increase sensitivity to osmotic stress, unmasking concealed conduction abnormalities.

Dissecting Gap Junctional and Ephaptic Contributions to Electrical Conduction in a Novel Cardiomyocyte Pair Model

This paper develops a novel cardiomyocyte pair model to quantify gap junction and ephaptic contributions to electrical conduction, showing that ephaptic mechanisms dominate at physiological sodium levels.

Hypernatremia Enhances Transient Outward Potassium and Late Sodium Currents in a Mouse Model of Long QT Syndrome Type 3

This study investigates how hypernatremia affects action potential duration in a mouse model of long QT syndrome type 3, finding that it increases transient outward potassium currents and alters repolarization patterns.

Age-dependent remodeling of the sciatic proteome in 5xFAD mice can be attenuated by exercise or donepezil treatment to maintain neuromuscular function

This study shows that exercise or donepezil treatment can reduce proteomic changes in sciatic nerves of 5xFAD mice, preserving neuromuscular function before cognitive decline.

Ephaptic coupling enables action potential conduction

This study demonstrates that ephaptic transmission can enable action potential conduction between cardiomyocytes, even in the presence of gap junctions, through shielded local domains.

Detection, Isolation and Quantification of Myocardial Infarct with Four Different Histological Staining Techniques

This paper develops a color-based algorithm to detect, isolate, and quantify myocardial infarct and fibrosis using four histological staining techniques.