Robert G. Gourdie

This study shows that Scn1b haploinsufficiency causes structural changes in cardiac intercalated discs that increase sensitivity to osmotic stress, unmasking concealed conduction abnormalities.

This paper develops a novel cardiomyocyte pair model to quantify gap junction and ephaptic contributions to electrical conduction, showing that ephaptic mechanisms dominate at physiological sodium levels.

This study investigates how hypernatremia affects action potential duration in a mouse model of long QT syndrome type 3, finding that it increases transient outward potassium currents and alters repolarization patterns.

This study identifies a novel peptide, JM2, that disrupts Cx43-microtubule interaction in GBM stem-like cells, reducing their survival and tumorigenicity.

This paper develops orally deliverable milk-derived nanovesicles loaded with Cx43 peptides to treat cardiac ischemia-reperfusion injury, showing >60% reduction in infarct size in mice.

This paper develops a color-based algorithm to detect, isolate, and quantify myocardial infarct and fibrosis using four histological staining techniques.