In situ deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic E. coli
Rajkamal Srivastava, Coral González-Prieto, Jason P. Lynch, Michele E. Muscolo, Catherine Y Lin, Markus A Brown, Luísa Lemos, Anishma Shrestha, Marcia S. Osburne, John M. Leong, Cammie F. Lesser
This study shows engineered commensal E. coli can deliver anti-EHEC Tir nanobodies to block pathogen colonization and improve survival in a mouse model.
PNAS Nexus · Sep 1, 2024Peer-reviewedMicrobiology