Author

Michele E. Muscolo

Tufts UniversityORCID 0009-0004-7653-0785Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Cammie F. LesseriD· 3 shared Anishma ShresthaiD· 1 shared Catherine Y LiniD· 1 shared Christine JacobsiD· 1 shared Coral González-Prieto· 1 shared Derfel TercianoiD· 1 shared Diana Fernandez Pacheco· 1 shared Hanh N. Lam· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

Cammie F. LesserORCID

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3 papers

Recent·Most cited

Differential targeting of human pyroptotic Caspase-5 and Caspase-4 by Shigella OspC2 and OspC3

Kyungsub Kim, Marcos Antonio Valdespino Diaz, Rowan Karr, Michele E. Muscolo, Lisa Goers, Truelian Yu, Tera C. Levin, Jonathan N. Pruneda, Cammie F. Lesser

This paper identifies OspC2 and OspC3 as Shigella effectors that specifically target Caspase-5 and Caspase-4, respectively, through their PCS domains, revealing evolutionary adaptations in host and pathogen interactions.

mBio · Feb 18, 2026Peer-reviewedMicrobiology

The polyadenylase PAPI is required for virulence plasmid maintenance in pathogenic bacteria

Katherine Schubert, Jessica Zhang, Michele E. Muscolo, Micah Braly, Joshua W. McCausland, Hanh N. Lam, Karen Hug, Matthew Loven, Santiago Ruiz Solis, Melissa Estrada Escobar, Henry Moore, Derfel Terciano, Diana Fernandez Pacheco, Todd M. Lowe, Cammie F. Lesser, , Victoria Auerbuch

This study identifies PAPI (encoded by pcnB) as essential for maintaining virulence and AMR plasmid copy number, stability, and bacterial virulence in Yersinia and Shigella.

PLoS Pathogens · May 27, 2025Peer-reviewedMicrobiology

In situ deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic E. coli

Rajkamal Srivastava, Coral González-Prieto, Jason P. Lynch, Michele E. Muscolo, Catherine Y Lin, Markus A Brown, Luísa Lemos, Anishma Shrestha, Marcia S. Osburne, John M. Leong, Cammie F. Lesser

This study shows engineered commensal E. coli can deliver anti-EHEC Tir nanobodies to block pathogen colonization and improve survival in a mouse model.

PNAS Nexus · Sep 1, 2024Peer-reviewedMicrobiology