Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic activity
Eric R. Greene, Richard Muniz, Hiroki Yamamura, Samuel Hoff, Priyanka Bajaj, Markus C.B. Tecson, Cyrina Geluz, D. John Lee, Erin M. Thompson, Angelika Arada, Gyun Min Lee, Massimiliano Bonomi, Justin M. Kollman, James S. Fraser
This paper shows human glutamine synthetase forms filaments stabilized by glutamine, reducing catalytic specificity for ammonia and linking product concentration to enzyme function.
eLife · Sep 25, 2026Peer-reviewedBioinformatics