D. John Lee

Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic activity

This paper shows human glutamine synthetase forms filaments stabilized by glutamine, reducing catalytic specificity for ammonia and linking product concentration to enzyme function.

Allosteric Disordering of eIF2B Regulates the Integrated Stress Response

This study identifies an allosteric mechanism in eIF2B that regulates the Integrated Stress Response by showing how eIF2-P binding inhibits eIF2B activity through latch-helix dislocation.

Stereoselective methyl-swapping demonstrates target specificity of cognitive enhancer

The paper demonstrates that a modified ISRIB analog selectively targets a mutant eIF2B, improving synaptic plasticity and memory in mice, confirming its on-target mechanism.

Harnessing the Evolution of Proteostasis Networks to Reverse Cognitive Dysfunction

This study investigates how a genetic variant disrupts proteostasis networks, leading to cognitive dysfunction, and identifies a viral protein that can reverse these deficits.