Samuel Hoff

This paper shows human glutamine synthetase forms filaments stabilized by glutamine, reducing catalytic specificity for ammonia and linking product concentration to enzyme function.

This paper introduces bAIes, a method that improves AlphaFold2 models using Bayesian inference to enhance virtual screening accuracy for drug discovery.

This study shows that acylation stabilizes the native fold of CyaA and facilitates its membrane orientation, revealing how post-translational modification drives toxin activity.