Hepatic retromer is essential for systemic cholesterol homeostasis by regulating lysosomal cholesterol metabolism
Dyonne Y. Vos, Markus Gregorio Barbosa, Andries Heida, Amandine Caillaud, Joël J. Tissink, Mirjam H. Koster, Marieke Smit, Nicolette Huijkman, Niels Kloosterhuis, Aurore Girardeau, Zoé Begué-Racapé, Vincent W. Bloks, Rick Havinga, Marceline Manka Fuh, Fulvio Reggiori, , Bart van de Sluis
This study shows that hepatic VPS35 deficiency disrupts lysosomal cholesterol metabolism, leading to increased cholesterol levels in plasma and liver.
bioRxiv · Aug 9, 2023 · PreprintMolecular Biology