Author

Niels Kloosterhuis

University Medical Center GroningenORCID 0009-0000-5500-3282Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Antoine RimbertiD· 2 shared Bart van de SluisiD· 2 shared Jan Albert KuivenhoveniD· 2 shared Justina Clarinda WoltersiD· 2 shared Marieke SmitiD· 2 shared Nicolette HuijkmaniD· 2 shared Alaa OthmaniD· 1 shared Amandine CaillaudiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCell Biology

Antoine RimbertORCID

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2 papers

Recent·Most cited

Cell BiologyAtherosclerosisPeer-reviewedAug 25, 2026

The COPI coatomer influences LDL receptor activity, hepatic lipid storage, and apoB secretion

Grigorios Panteloglou, Jérôme Robert, Marieke Smit…·Arnold von Eckardstein

This study identifies COPI coatomer subunits that regulate LDL receptor activity, apoB secretion, and hepatic lipid storage, with genetic variants linked to elevated LDL-C levels.

DOI 10.1016/j.atherosclerosis.2026.121887

humanmouse

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Molecular BiologybioRxivPreprintAug 9, 2023

Hepatic retromer is essential for systemic cholesterol homeostasis by regulating lysosomal cholesterol metabolism

Dyonne Y. Vos, Markus Gregorio Barbosa, Andries Heida…·Bart van de Sluis

This study shows that hepatic VPS35 deficiency disrupts lysosomal cholesterol metabolism, leading to increased cholesterol levels in plasma and liver.

DOI 10.1101/2023.08.09.552611

mouseexperimental assay

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