A High-Throughput Biocatalytic Platform for Screening Isomeric Kainoid Natural Products
Robert A. Shepherd, Manasa Ramachandra, Austin R. Hopiavuori, Marla Jones, Conrad A. Fihn, Alex J. Tabag, Ananya Manjunath, Limar Y. Gad, Chloe R. Whipple, Shaun M. K. McKinnie, Laura M. Sanchez
The paper develops a MALDI-TIMS-MS platform for high-throughput screening of isomeric product ratios from enzyme libraries, identifying variants with improved KAL conversion.
Cell Reports Physical Science · Feb 1, 2026Peer-reviewedBioengineering