Laura M. Sanchez

This study shows Achromobacter spp. enhance Pseudomonas aeruginosa virulence by inducing siderophore production through iron competition in CF airways.

This paper integrates MALDI-MS/MS into a bioinformatics platform to enable rapid metabolite annotation and strain prioritization from microbial colonies.

Tensile stretching of live, unfixed OVCAR8 cells on a fibronectin-functionalized double-network hydrogel expands them about 1.7x linearly, enabling single-cell MALDI metabolite imaging on unmodified commercial instruments.

IDBac provides a centralized database and platform for bacterial identification via MALDI-TOF MS, enabling spectral comparison and analysis of bacterial isolates.

This paper introduces TExM, a method to super-resolve fixed and live cellular samples by mechanically expanding hydrogels during continuous imaging.

The paper uses MALDI-FISH to co-localize brominated metabolites and Pseudovibrio spp. in sponge tissue, suggesting both sponge and microbe may be required for metabolite production.

The paper develops a MALDI-TIMS-MS platform for high-throughput screening of isomeric product ratios from enzyme libraries, identifying variants with improved KAL conversion.

This study identifies enzymes involved in amino acid incorporation into the antibiotic TLN-05220 using metabolomic and genomic analyses.

This paper identifies how Aspergillus westerdijkiae uses penicillic acid and other metabolites to inhibit cheese rind bacteria, disrupting microbial communities through chemical interactions.

This paper demonstrates the use of MALDI iprm-PASEF to rapidly and accurately annotate coproporphyrin III in a fungal-bacterial co-culture.

This study identifies increased branched-chain amino acid catabolism in ovarian cancer cells interacting with omental tissue, promoting proliferation via mTOR signaling.

This study compares SICRIT and ESI ionization methods in microbial metabolomics, finding SICRIT ionizes different metabolites and more efficiently ionizes lipids in positive mode.

The paper identifies a subfamily of vanadium-dependent haloperoxidases that brominate alkyl quinolone quorum sensing signals, revealing their role in microbial chemical ecology.

MassQL, an open-source query language, lets users search raw mass spectrometry data from any vendor for isotope, fragmentation and neutral-loss patterns, from one file to entire public repositories.

TIMSCONVERT converts trapped ion mobility data to open formats for compatibility with downstream analysis tools.