Prefrontal dopamine activity is critical for rapid threat avoidance learning
Zachary Zeidler, Marta Fernandez Gomez, Tanya A. Gupta, Meelan Shari, Scott A. Wilke, Laura A. DeNardo
This study shows that dopamine signaling in the VTA-mPFC circuit is essential for rapid threat avoidance learning, with transient dopamine activity encoding aversive outcomes and predictive cues.
Current Biology · Aug 8, 2025Peer-reviewedNeuroscience