Laura A. DeNardo

Early adversity promotes adolescent avoidance behavior by enhancing prefrontal-amygdala communication through CRH+ glutamatergic neurons

This study shows that early adversity enhances prefrontal-amygdala communication via CRH+ glutamatergic neurons, leading to increased adolescent avoidance behavior.

A cell type-specific mechanism driving the rapid antidepressant effects of transcranial magnetic stimulation

This study identifies a cell type-specific mechanism in the prefrontal cortex that underlies the rapid antidepressant effects of a specific rTMS protocol in a mouse model.

Sex-and Stress-Dependent Plasticity of a Corticotropin Releasing Hormone / GABA Projection from the Basolateral Amygdala to Nucleus Accumbens that Mediates Reward Behaviors

The paper investigates sex- and stress-dependent plasticity of a CRH/GABA projection from the BLA to NAc, showing differential effects on reward behaviors in males and females.

Prefrontal dopamine activity is critical for rapid threat avoidance learning

This study shows that dopamine signaling in the VTA-mPFC circuit is essential for rapid threat avoidance learning, with transient dopamine activity encoding aversive outcomes and predictive cues.

Directed cell-type recruitment during consolidation of a remote memory

The paper identifies prefrontal projection neurons recruited during remote memory consolidation through synaptic activity of learning-activated cells.

Transformations in prefrontal ensemble activity underlying rapid threat avoidance learning

This study investigates how prefrontal cortex activity changes during rapid threat avoidance learning in mice, finding that population dynamics precede single-neuron encoding changes.

Microglia regulate nucleus accumbens synaptic development and circuit function underlying threat avoidance behaviors

This study shows that microglia are essential for excitatory synapse formation in the nucleus accumbens during early development, impacting threat avoidance behaviors in adulthood.

A developmental brain-wide screen identifies retrosplenial cortex as a key player in the emergence of persistent memory

The paper identifies the retrosplenial cortex as critical for the emergence of persistent memory through developmental studies in mice.

Developmentally distinct architectures in top-down circuits

This study investigates how developmental changes in mPFC circuits influence behavioral strategies in juvenile, adolescent, and adult mice by manipulating and monitoring brain activity during threat responses.

Brain-wide projections and differential encoding of prefrontal neuronal classes underlying learned and innate threat avoidance

The paper maps brain-wide projections of mPFC neurons and identifies their specialized roles in threat avoidance using new computational tools.

BehaviorDEPOT: a tool for automated behavior classification and analysis in rodents

BehaviorDEPOT automates behavior classification and analysis in rodents, providing tools for tracking, classification, and experimental setup with reduced costs and improved reliability.

Neural activity in the anterior cingulate cortex is required for effort-based decision making

This study shows that neural activity in the anterior cingulate cortex is necessary for making effort-based decisions by using optogenetic manipulation in a mouse model.

Temporal Evolution of Cortical Ensembles Promoting Remote Memory Retrieval

The paper uses TRAP2 to study how prefrontal cortex neurons involved in memory retrieval change over time and support remote memory.

Amyloid accumulation drives proteome-wide alterations in mouse models of Alzheimers disease like pathology

The paper identifies proteome-wide changes in mouse models of Alzheimer's disease, highlighting ApoE dysregulation and synaptic protein loss.