E3 ubiquitin-ligase Hakai induces LRP4 degradation and regulates Wnt/beta-catenin signalling in colorectal cancer cells
Andrea Rodríguez-Alonso, Lía Jove, Gloria Alfonsín, Marta M. Tasende, Ingrid Jordens, Madelon M. Maurice, Angélica Figueroa
This study shows that Hakai promotes colorectal cancer stem cell traits by enhancing Wnt/beta-catenin signaling through LRP4 degradation and that Hakin-1 inhibits these effects.
bioRxiv · Nov 20, 2025 · PreprintCancer Biology