Madelon M. Maurice

This study shows WNT7B drives pancreatic cancer subtype switching and progression by promoting a basal-like state and influencing cell communication within tumors.

This study shows that AXIN1 mutations in HCC lead to reduced Wnt/β-catenin activity and increased YAP/TAZ signaling, enabling niche-independent growth.

This study shows that Hakai promotes colorectal cancer stem cell traits by enhancing Wnt/beta-catenin signaling through LRP4 degradation and that Hakin-1 inhibits these effects.

This study identifies WNK kinases as regulators of RNF43, showing they control RNF43 membrane levels and WNT signaling, with implications for cancer therapy.