Development of a universal nanobody-binding Fab module for fiducial-assisted cryo- EM studies of membrane proteins
Joël S. Bloch, Somnath Mukherjee, Julia Kowal, Ekaterina V. Filippova, Martina Niederer, Els Pardon, Jan Steyaert, Anthony A. Kossiakoff, Kaspar P. Locher
The paper develops a synthetic Fab module (NabFab) that binds nanobodies with high affinity, enabling high-resolution cryo-EM studies of membrane proteins.
Proceedings of the National Academy of Sciences · Nov 15, 2021Peer-reviewedMolecular Biology