Author

Kaspar P. Locher

ETH ZurichORCID 0000-0002-8207-2889Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Joël S. BlochiD· 2 shared Ana S. RamίreziD· 1 shared Anthony A. KossiakoffiD· 1 shared Bruno Stieger· 1 shared Edward V. QuadrosiD· 1 shared Ekaterina V. FilippovaiD· 1 shared Els PardoniD· 1 shared Jan SteyaertiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMolecular Biology

Joël S. BlochORCID

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3 papers

Recent·Most cited

Functional Reconstitution of Human OATP1B1 and OATP1B3 in Proteoliposomes: Effect of Bicarbonate Gradients and Substrate-specific Stimulation on Transport

Juan Carlos Mellado Tenorio, Stephen J. Butler, Bruno Stieger, Kaspar P Locher

This study reconstitutes OATP1B1 and OATP1B3 in proteoliposomes to show bicarbonate gradients drive substrate uptake, with EGCG enhancing OATP1B3 transport.

bioRxiv · Nov 3, 2026 · PreprintBiochemistry

Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B12 uptake route.

Joël S. Bloch, Jeffrey M. Sequeira, Ana S. Ramίrez, Edward V. Quadros, Kaspar P. Locher

The paper develops nanobodies targeting the human transcobalamin-mediated vitamin B12 uptake route and shows their potential to inhibit cancer cell growth.

The FASEB Journal · Feb 26, 2022Peer-reviewedMolecular Biology

Development of a universal nanobody-binding Fab module for fiducial-assisted cryo- EM studies of membrane proteins

Joël S. Bloch, Somnath Mukherjee, Julia Kowal, Ekaterina V. Filippova, Martina Niederer, Els Pardon, Jan Steyaert, Anthony A. Kossiakoff, Kaspar P. Locher

The paper develops a synthetic Fab module (NabFab) that binds nanobodies with high affinity, enabling high-resolution cryo-EM studies of membrane proteins.

Proceedings of the National Academy of Sciences · Nov 15, 2021Peer-reviewedMolecular Biology