Lipotoxic fingerprints in clinically relevant postoperative pancreatic fistula: fatty acid driven cytotoxicity targets cells involved in anastomotic healing
Johannes David Lettner, Marvin Schwarzer, Simon Lagies, Bernd Kammerer, Stephanie Mewes, Sophia Chikhladze, Stefan Fichtner‐Feigl, Geoffroy Andrieux, Dietrich Alexander Ruess, Uwe A. Wittel
This study identifies fatty acid-driven cytotoxicity in postoperative pancreatic fistula effluents and links it to cellular injury and transcriptional stress responses in anastomotic healing.
bioRxiv · Feb 13, 2026 · PreprintCell Biology