Dietrich Alexander Ruess

This study investigates the immunomodulatory effects of SHP2-based vertical RAS pathway inhibition in pancreatic cancer, revealing both immune-activating and suppressive changes that evolve with treatment.

This study identifies fatty acid-driven cytotoxicity in postoperative pancreatic fistula effluents and links it to cellular injury and transcriptional stress responses in anastomotic healing.

This study shows that dual SHP2/MEK inhibition in pancreatic cancer causes mitochondrial changes and ROS elevation, leading to a therapy-resistant state that can be targeted with GPX4 inhibition.

This study identifies c-Rel as a driver of pancreatic cancer metastasis by promoting EMT, ECM remodeling, and resistance to isolation stress through fibronectin-integrin signaling.

The paper reports germline recombination in Ptf1a-driven Cre mouse lines when the Cre allele is paternally transmitted, emphasizing the need for genotyping and maternal transmission to avoid unintended recombination.