Geoffroy Andrieux

Loss of CD44 re-educates pancreatic cancer-associated fibroblasts modulating their fibrotic and immunosuppressive functions

This study shows that CD44 deletion in pancreatic cancer-associated fibroblasts reduces tumor volume, alters their morphology and function, and enhances anti-tumor immune responses.

CD117 epitope-shielded hematopoietic stem cell transplantation with toxin-free conditioning and in vivo selection ameliorates β-thalassemia model

This paper demonstrates a method using CD117-blocking antibody and epitope-engineered HSPCs to treat β-thalassemia without myeloablative conditioning.

Spatially confined niches support hypoxia-associated transcriptional plasticity contributing to malignant progression in IDH-mutant gliomas

This study identifies hypoxia-associated transcriptional plasticity in IDH-mutant gliomas, showing microglia-driven quiescent-to-activated transitions that drive malignant progression.

Inhibition of IAPs induces programmed cell death and inflammatory signaling in patient-derived metastatic breast cancer organoids

This study shows that Smac mimetics induce apoptosis in breast cancer organoids and that necroptosis, associated with inflammation, can be inhibited by LUBAC inhibitors.

Immunomodulatory impact of PTPN11/SHP2-based vertical RAS-MAPK pathway inhibition in pancreatic cancer

This study investigates the immunomodulatory effects of SHP2-based vertical RAS pathway inhibition in pancreatic cancer, revealing both immune-activating and suppressive changes that evolve with treatment.

Castling, a novel therapeutic concept for rewiring pathological gene-expression networks, enabled by the TRIPLE technology

The paper introduces a therapeutic strategy called castling to correct gene-expression imbalances by rewiring miRNA regulation using the TRIPLE genome-editing technology.

Lipotoxic fingerprints in clinically relevant postoperative pancreatic fistula: fatty acid driven cytotoxicity targets cells involved in anastomotic healing

This study identifies fatty acid-driven cytotoxicity in postoperative pancreatic fistula effluents and links it to cellular injury and transcriptional stress responses in anastomotic healing.

Vertical RAS-pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations

This study shows that dual SHP2/MEK inhibition in pancreatic cancer causes mitochondrial changes and ROS elevation, leading to a therapy-resistant state that can be targeted with GPX4 inhibition.

Repurposing base editors for targeted knock-in and simultaneous knockouts to generate multiplex-edited allogeneic CAR T cells with minimal translocations

This paper develops BEKI, a base editor-based method for targeted transgene insertion and multiplex gene disruption in T cells, reducing chromosomal translocations compared to Cas9-based approaches.

Reprogramming Immunosuppressive Bone Marrow Derived Cells via CD44 Targeting Impacts Pancreatic Cancer Metastasis

This study shows targeting CD44 on bone marrow-derived cells reduces pancreatic cancer metastasis by disrupting immunosuppressive niches in the liver.

Microtubule anchoring and coupling of CD20 to the RhoA/Rock1 pathway

This study shows CD20 phosphorylation by PKCδ links it to the RhoA/Rock1 pathway via 14-3-3 and GEF-H1, regulating MT stability and actomyosin contractility in B cells.

Hematological phenotypes in GATA2 deficiency syndrome arise from secondary injuries and maladaptation to proliferation

This study shows that GATA2 deficiency leads to hematological issues through bone marrow failure and maladaptation, with leukemia arising from genomic instability and proliferation defects.

Breaking the cycle: How targeting CD44v6/MET signaling disrupts colorectal cancer cell plasticity

This study shows that targeting CD44v6/MET signaling disrupts colorectal cancer cell plasticity by repressing Lgr5+ cell reappearance and affecting YAP/TAZ signaling.

The amyloid precursor protein regulates synaptic transmission at medial perforant path synapses

This study investigates the role of amyloid precursor protein (APP) in synaptic transmission at medial perforant path synapses using organotypic cultures and finds that presynaptic APP affects neurotransmission efficacy.

Tumor necrosis factor α modulates excitatory and inhibitory neurotransmission in a concentration-dependent manner

This study shows that TNF affects excitatory and inhibitory neurotransmission differently at low and high concentrations, with high concentrations activating microglia and inducing homeostatic effects.