Genetic or pharmacological disruption of the MSH3 Y245/K246 IDL binding pocket slows CAG repeat expansion
Rob Goold, Jasmine Donaldson, Florence Gidney, Philip Goff, Joseph Hamilton, Marwa Elmasri, Lucy Coupland, Michael D. Flower, Sarah J. Tabrizi
This study shows disrupting the MSH3 Y245/K246 DNA binding pocket reduces CAG repeat expansion in Huntington's disease models.
NAR Molecular Medicine · Mar 30, 2026Peer-reviewedNeuroscience