Self-reactive human CD8⁺ T cells restricted by HLA-E mediate immunoregulatory and antiviral functions
Lucy C. Walters, Xuan Guo, Carlos Casquero, Jonathan M. Urbach, Owen Leddy, Elif Çakan, Amanda O. Chan, Pallavi A. Balivada, Hannah Wisner, Bryan D. Bryson, Forest M. White, Mary Carrington, David R. Collins, Michael E. Birnbaum, Bruce D. Walker
The paper identifies E-sensors, HLA-E-restricted CD8+ T cells that recognize increased self-VL9/HLA-E, mediating immunoregulation and antiviral responses in HIV control.
bioRxiv · Oct 13, 2026 · PreprintImmunology