Michael E. Birnbaum

The paper identifies bottlenecks in MHC-I antigen presentation by Mtb, showing that only a small fraction of predicted binders are actually presented, and develops computational models to improve prediction.

The paper identifies E-sensors, HLA-E-restricted CD8+ T cells that recognize increased self-VL9/HLA-E, mediating immunoregulation and antiviral responses in HIV control.

This paper develops 4-1BB-targeting lentiviral vectors to selectively expand and transduce antigen-specific T cells, enhancing their function in cancer immunotherapy.

This study examines how the duration of initial HIV-1 viremia affects the functional properties of HIV-specific T cell receptors in individuals with HLA-B*58:01.

The paper introduces a scalable TCR synthesis and screening method, TCRAFT, to map antigen reactivity in vitiligo and pancreatic ductal adenocarcinoma.

This paper develops ARCADE, a high-throughput assay to profile antiviral antibody responses, showing mRNA vaccines elicit broader and stronger responses than adenovirus vector vaccines.

This paper introduces a yeast surface display pipeline to screen for class I peptide MHC binders across multiple alleles and applies it to pathogen proteomes to identify potential T cell antigens.

This study develops pMHC-targeted retroviruses for in vivo gene delivery to tumor-specific T cells, enhancing their expansion and anti-tumor activity in mouse models.

This study designs factorizable antibody libraries using neural networks, finding they outperform random and enumerated libraries in pMHC binding.

The paper introduces VelociRAPTR, a method to map TCR-antigen interactions by combining yeast-displayed TCR libraries with pMHC-displaying virus-like particles, revealing biased recognition patterns and enabling TCR engineering.

The paper designs and characterizes ComMAND, a microRNA-based gene circuit that precisely controls transgene expression in diverse primary cells.

This paper evaluates using FAD autofluorescence as a label-free biomarker to monitor T cell activation and expansion in CAR-T cell production.

This paper develops a modeling framework to estimate T cell metabolic rates during CAR T cell production and shows correlations between early metabolism and final product attributes.

The paper identifies novel IL13Rα2-targeted CARs with improved anti-glioblastoma efficacy using a pooled screening platform.

The paper uses single-cell sequencing to analyze CAR signaling and identifies ICD architectures that promote durable in vivo persistence in liquid tumors.