A Novel Mechanism of Cardiomyopathy: Toxic Peptides Dysregulate Calcium Transport
Taylor A. Phillips, Jacob D. Cunningham, Mary D. Hernando, Jaroslava Šeflová, Laura A. Sherer, Seby Louis Edassery, Jonathan A. Kirk, Howard S. Young, Seth L. Robia
The paper identifies toxic transmembrane peptides that inhibit SERCA function in DCM, offering a new mechanism for calcium mishandling in heart failure.
bioRxiv · Apr 28, 2026 · PreprintPhysiology