Jonathan A. Kirk

A Novel Mechanism of Cardiomyopathy: Toxic Peptides Dysregulate Calcium Transport

The paper identifies toxic transmembrane peptides that inhibit SERCA function in DCM, offering a new mechanism for calcium mishandling in heart failure.

Polycystin-2 is cardioprotective against myocardial infarction by regulating the calcium-mediated ER stress response.

This paper shows that Polycystin-2 protects the heart from myocardial infarction by regulating calcium-mediated ER stress response in cardiomyocytes.

Molecular mechanisms of GSK3β-driven modulation of ABLIM1 and titin interactions in cardiac muscle

This study investigates how phosphorylation of ABLIM1's intrinsically disordered regions modulates its interaction with titin, affecting cardiac muscle contraction.

Titin cleavage impairs cardiac mechanical connectivity to drive diastolic failure and fibrosis

This study shows that titin cleavage in mice causes concentric cardiac remodeling, diastolic dysfunction, and fibrosis by disrupting mechanical connectivity.

Calcium-Activated Sarcomere Contractility Drives Cardiomyocyte Maturation and the Response to External Mechanical Cues but is Dispensable for Sarcomere Formation

This study shows calcium-activated contractility is not needed for sarcomere formation but is essential for cardiomyocyte maturation and response to mechanical cues, with nanopatterns aiding maturation in non-contractile cells.