Stepwise Evolution and Epistatic Interaction of Driver Mutations from Endometrial Hyperplasia to Carcinoma
Mary F Summers, Kira A. Glasmacher, Sem Asmelash, Jeffrey D. Mandell, Jeffrey Nicholas Fisk, Jeffrey P. Townsend, Vincent L. Cannataro
This study analyzes the evolutionary dynamics of driver mutations during endometrial hyperplasia to carcinoma progression, revealing differences in selection pressures and epistatic interactions between mutation pairs.
bioRxiv · Jun 30, 2026 · PreprintCancer Biology