Vincent L. Cannataro

Stepwise Evolution and Epistatic Interaction of Driver Mutations from Endometrial Hyperplasia to Carcinoma

This study analyzes the evolutionary dynamics of driver mutations during endometrial hyperplasia to carcinoma progression, revealing differences in selection pressures and epistatic interactions between mutation pairs.

Somatic evolution of prostate cancer: mutation, selection, and epistasis across disease stages

This study quantifies mutation rates, selection coefficients, and epistatic interactions across prostate cancer stages, revealing dynamic selective pressures and therapeutic implications.

Cancer relevance of human genes

The paper identifies cancer-relevant genes by analyzing their proximity to core cancer genes in protein-protein interaction networks, finding that genes closer to cancer genes show greater functional importance in cancer biology.

Identifying Combinations of Cancer Drivers in Individual Patients

This paper introduces CRSO to identify cancer driver combinations in individual patients, showing that rule-based analysis improves outcome prediction compared to single-alteration analysis.