Non-cell-autonomous regulation of germline proteostasis by insulin/IGF-1 signaling via the intestinal peptide transporter PEPT-1
Tahir Muhammad, Stacey L. Edwards, Allison C. Morphis, Mary V. Johnson, Vitor De Oliveira, Tomasz Chamera, Siyan Liu, Ngoc Gia Tuong Nguyen, Jian Li
The paper shows that insulin/IGF-1 signaling regulates germline proteostasis in C. elegans by promoting dietary protein absorption through the intestinal transporter PEPT-1.
bioRxiv · Feb 22, 2024 · PreprintDevelopmental Biology