Jian Li

This study identifies TIMM17A as a key mediator of HSF1-driven mitochondrial biogenesis and function in cancer cells, revealing a mechanism linking HSF1 to mitochondrial protein import and energy production.

The paper shows that insulin/IGF-1 signaling regulates germline proteostasis in C. elegans by promoting dietary protein absorption through the intestinal transporter PEPT-1.

The paper constructs a coessential genetic network to map the dynamic cellular stress response across 625 cancer cell lines, identifying key regulators and modules involved in stress resilience.