Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4+ cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype
Camila D. Arcuschin, Kamin Kahrizi, Rosalyn W. Sayaman, Carolina Di Benedetto, Pedro J Salaberry, Roxana Pirker, Yizhuo Shen, Ons Zakraoui, Cecilia Schwarzer, Alessandro Scapozza, Joseph A. Caruso, Paola A. Betancur, Julie Deane Saba, Jean‐Philippe Coppé, Mary-Helen Barcellos-Hoff, , Denise P. Muñoz
The paper identifies ThPOK/ZBTB7B as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype by suppressing metastatic pathways.
Cellular and Molecular Life Sciences · Nov 13, 2025Peer-reviewedCancer Biology