Author

Joseph A. Caruso

University of California, San FranciscoORCID 0000-0003-2900-3996Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Philippe D. GascardiD· 3 shared Thea Dorothy TlstyiD· 3 shared Birgit SchillingiD· 2 shared Chira Chen‐Tanyolac· 2 shared David L. GibbsiD· 2 shared Deng Pan· 2 shared Jiannis RagoussisiD· 2 shared Joanna BonsiD· 2 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Philippe D. GascardORCID

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4 papers

Recent·Most cited

Cancer BiologyCellular and Molecular Life SciencesPeer-reviewedNov 13, 2025

Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4+ cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype

Camila D. Arcuschin, Kamin Kahrizi, Rosalyn W. Sayaman…·Denise P. Muñoz

The paper identifies ThPOK/ZBTB7B as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype by suppressing metastatic pathways.

2 citations

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintAug 25, 2025

A fibroblast-centric network drives cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma

Shoval Miyara, Shachaf Frenkel, Avi Mayo…·Uri Alon

The paper identifies a cold fibrotic network in LUSC TME driven by CAFs and shows its conservation in other CIACs, suggesting therapeutic targets.

2 citations

humanscRNA-seq

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Cancer BiologybioRxivPreprintJul 11, 2025

A Fibroblast State Choreographs an Epithelial YAP-dependent Regenerative Program Essential to (Pre)malignancy via ECM-mediated Mechanotransduction

Deng Pan, Philippe D. Gascard, Joseph A. Caruso…·Thea Dorothy Tlsty

The paper identifies a fibroblast state called STIF that drives YAP-dependent regenerative programs and (pre)malignancy through mechanotransduction in response to tissue injury.

2 citations

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintJan 21, 2025

Proteomic Analysis of Breast Cancer Subtypes Identifies Stromal Protein Profiles that Contribute to Aggressive Malignant Behavior

Jordan B. Burton, Philippe D. Gascard, Deng Pan…·Thea Dorothy Tlsty

The paper identifies stromal protein profiles in breast cancer subtypes using proteomic analysis of FFPE tissues, revealing significant ECM and immune-related changes, particularly in metaplastic breast cancer.

DOI 10.1101/2025.01.21.634187

humanproteomics

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