Colchicine Directly Targets Aldehyde Dehydrogenase 2 (ALDH2) to Suppress Radiation-Induced Senescence and Atherosclerosis
Jun‐ichi Abe, Venkata Subrahman K Samanthapudi, Weiqing Chen, Jonghae Lee, Ngoc Tuyet Tra, Gilbert F. Mejia, Oanh N. Hoang, Luis Antonio Rivera, Kun Yuan Chu, Masaki Osawa, Jung Hyun Kim, Shengyu Li, Kyung Ae Ko, Anilkumar K. Reddy, Silvia Fernanda López Moreno, , Sivareddy Kotla
This study identifies ALDH2 as a direct target of colchicine, showing it suppresses radiation-induced senescence and atherosclerosis by modulating mitochondrial redox and macrophage function.
bioRxiv · May 30, 2026 · PreprintCell Biology