Mevalonate pathway activation in Ewing sarcoma reveals a 3D-specific synergy between statins and BCL-xL inhibition
Branka Radic-Sarikas, Marica Marković, Martha Magdalena Zylka, Caterina Sturtzel, Mathias Ilg, Didier Surdez, Martin Lothar Metzelder, Martin Distel, Aleksandr Ovsianikov, Florian Halbritter, Heinrich Kovar
The paper develops a 3D culture platform for Ewing sarcoma and identifies a synergy between statins and BCL-xL inhibitors targeting the mevalonate pathway.
Molecular Therapy Oncology · May 9, 2026Peer-reviewedCancer Biology