High-throughput single-cell CRISPRi screens stratify neurodevelopmental functions of schizophrenia-associated genes
Umut Yildiz, Annique Claringbould, Mikael Marttinen, Víctor Campos-Fornés, Mantha Lamprousi, Manu Saraswat, Mathias Saver, Daria Bunina, Michael W. Dorrity, Judith B. Zaugg, Kyung‐Min Noh
The paper uses single-cell CRISPRi screens to functionally assess schizophrenia-associated genes, revealing disruptions in neurodevelopmental timing and identifying key regulatory factors.
bioRxiv · Jun 13, 2025 · PreprintNeuroscience