Umut Yildiz

Sodium Aurothiomalate Induces Ferroptosis by Targeting GPX4 via Gold-Dependent Thiomalate Covalent Modification

This study shows sodium aurothiomalate induces ferroptosis by covalently modifying GPX4 through a gold-dependent mechanism, leading to tumor growth reduction in preclinical models.

High-throughput single-cell CRISPRi screens stratify neurodevelopmental functions of schizophrenia-associated genes

The paper uses single-cell CRISPRi screens to functionally assess schizophrenia-associated genes, revealing disruptions in neurodevelopmental timing and identifying key regulatory factors.

PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance

The paper identifies PRDX6 as an alternative pathway for selenocysteine metabolism that contributes to ferroptosis resistance in cancer cells.

Histone H3.3 lysine 9 and 27 control repressive chromatin states at cryptic cis-regulatory elements and bivalent promoters in mouse embryonic stem cells

This study shows that H3.3K9 and K27 modifications regulate repressive chromatin states at cis-regulatory elements and bivalent promoters in mESCs, affecting gene expression.

Functional phenotyping of genomic variants using multiomic scDNA-scRNA-seq

This paper introduces SDR-seq, a multiomic scDNA-scRNA-seq method to link genotypes with gene expression, showing variants affect expression in iPSCs and B-cell lymphoma.

Scalable ultra-high-throughput single-cell chromatin and RNA sequencing reveals gene regulatory dynamics linking macrophage polarization to autoimmune disease

This paper introduces SUM-seq, a scalable multiomic method for single-cell chromatin and RNA sequencing, revealing gene regulatory dynamics in macrophage polarization linked to autoimmune diseases.