Kyung‐Min Noh

Fast calcium-dependent fluorescent labeling for recording of neuronal activation

The paper introduces faster variants of the Caprola tool for calcium-dependent fluorescent labeling, enabling more sensitive and efficient recording of neuronal activity in zebrafish.

Dual role of ZIC2 during neural induction: from pioneer transcription factor to enhancer activator

This study investigates ZIC2's role in neural development, showing it acts as a pioneer transcription factor during pluripotency exit and an enhancer activator during neural induction.

High-throughput single-cell CRISPRi screens stratify neurodevelopmental functions of schizophrenia-associated genes

The paper uses single-cell CRISPRi screens to functionally assess schizophrenia-associated genes, revealing disruptions in neurodevelopmental timing and identifying key regulatory factors.

Histone H3.3 lysine 9 and 27 control repressive chromatin states at cryptic cis-regulatory elements and bivalent promoters in mouse embryonic stem cells

This study shows that H3.3K9 and K27 modifications regulate repressive chromatin states at cis-regulatory elements and bivalent promoters in mESCs, affecting gene expression.

Functional phenotyping of genomic variants using multiomic scDNA-scRNA-seq

This paper introduces SDR-seq, a multiomic scDNA-scRNA-seq method to link genotypes with gene expression, showing variants affect expression in iPSCs and B-cell lymphoma.

Scalable ultra-high-throughput single-cell chromatin and RNA sequencing reveals gene regulatory dynamics linking macrophage polarization to autoimmune disease

This paper introduces SUM-seq, a scalable multiomic method for single-cell chromatin and RNA sequencing, revealing gene regulatory dynamics in macrophage polarization linked to autoimmune diseases.

Lipotype acquisition during neural development in vivo is not recapitulated in stem cell-derived neurons

This study shows that mouse brain lipotypes develop in two stages, with cholesterol increasing postnatally, and that stem cell-derived neurons do not fully recapitulate this lipotype.

Multi-omic profiling of histone variant H3.3 lysine 27 methylation reveals a distinct role from canonical H3 in stem cell differentiation

The paper investigates the role of H3.3K27me3 in mouse embryonic stem cell differentiation, showing it regulates distinct terminal differentiation genes compared to canonical H3K27me3.

The neurodevelopmental disorder-linked PHF14 complex that forms biomolecular condensates detects DNA damage and promotes repair

This study identifies the PHF14 complex's role in DNA damage detection and repair through biomolecular condensate formation, showing its importance in neural progenitor cell function.

Pathological LSD1 mutations repress enhancer-mediated gene regulatory networks in early differentiation

The paper identifies gene regulatory network disruptions caused by LSD1 mutations in early differentiation, showing impaired transcription factor activity and potential therapeutic targets through HDAC inhibition.

Comparative chromatin accessibility upon BDNF-induced neuronal activity delineates neuronal regulatory elements

The paper identifies BDNF-specific chromatin accessibility changes in neurons and links them to gene regulation and neurodevelopmental traits.

The functional landscape of the human phosphoproteome

The paper creates a comprehensive human phosphoproteome by integrating 6,801 phospho-enriched mass spectrometry experiments and prioritizes functional phosphosites using machine learning.

Efficient strategies to detect genome editing and integrity in CRISPR-Cas9 engineered ESCs

The paper describes an experimental strategy for mutating protein residues in mouse ESCs and introduces Mismatch-qPCR for detecting CRISPR editing events, while also showing RNA-Seq and low-coverage sequencing can detect large chromosomal deletions and rearrangements.