Dual-stage inhibition of Plasmodium falciparum by a Skeletocutis derived fungal metabolite targeting Pyruvate Kinase II
Lucille Hervé, Nadia Amanzougaghene, Séverine Amand, Magali Blaud, Romain Coppée, Zaineb Fourati, Jean‐François Franetich, Quentin GOOR, Sandrine Houzé, Murielle Lohezic, Mathilde Patat, Véronique Sarrasin, Emilie Zélie, Valérie Soulard, Stéphane Mann, Anaïs Merckx
This study identifies skeletocutin E as a dual-stage antimalarial compound that inhibits Plasmodium falciparum pyruvate kinase II, showing efficacy against both blood and liver stages of the parasite.
bioRxiv · Mar 18, 2026 · PreprintMicrobiology