Optics-free reconstruction of shapes, images and volumes with DNA barcode proximity graphs
Hanna Liao, Sanjay V. Kottapalli, Yuqi Huang, Matthew Chaw, Jase Gehring, Olivia G. Waltner, Melissa Phung-Rojas, Riza M. Daza, Frederick A. Matsen IV, Cole Trapnell, Jay Shendure, Sanjay R Srivatsan
The paper introduces SCOPE, an optics-free method to reconstruct 2D and 3D shapes using DNA barcode proximity graphs from sequencing data.
bioRxiv · Aug 6, 2024 · PreprintGenomics