Hanna Liao

The paper introduces OPTIMuS PRIME-Del, a CRISPR-based method for multiplexed, precise deletion of cis-regulatory elements, validated through molecular tagging and scRNA-seq analysis.

The paper develops monoclonal gastruloids from single mouse embryonic stem cells and uses DNA Typewriter to reveal heritable lineage biases in early development.

This paper introduces P3 editing, a method that links protein-protein proximity to CRISPR-Cas9 dual-component guide RNA formation, enabling genome editing triggered by molecular interactions in human cells.

The paper designs and characterizes diverse genomic parts for precise genome editing and molecular recording in mammalian cells.

The paper introduces SCOPE, an optics-free method to reconstruct 2D and 3D shapes using DNA barcode proximity graphs from sequencing data.

The paper constructs a genome-scale transcriptional regulatory network of the human placenta using genomic and transcriptomic data, identifying key regulators of preterm birth.

The paper identifies LUTI candidates during meiotic prophase and shows that LUTI-based repression integrates translational and transcriptional mechanisms.

This study demonstrates precise control of gene expression levels by targeting the KRAB repressor domain in human cells.

This study shows that Aurora B-dependent phosphorylation of Ndc80 promotes its degradation during meiosis, regulating kinetochore composition and preventing chromosome mis-segregation.