OPA1 mediates cardiac function and metabolism: in silico and in vivo evidence
Claire Fong-McMaster, Serena M. Pulente, Luke S Kennedy, Tyler K.T. Smith, Stephanie Myers, Michel N Kanaan, Charbel Y Karam, Matthew Cope, Michelle M. Levesque, Ella McIlroy, Ilka Lorenzen‐Schmidt, Craig J. Goergen, Morgan D. Fullerton, Miroslava Čuperlović‐Culf, Erin E. Mulvihill, Mary‐Ellen Harper
The paper investigates OPA1's role in cardiac function and metabolism using in silico and in vivo approaches, finding that OPA1 overexpression improves cardiac function and maintains metabolic markers in a mouse model.
BMC Cardiovascular Disorders · Dec 9, 2025Peer-reviewedBiochemistry