Author

Tyler K.T. Smith

University of OttawaORCID 0000-0002-8013-4660Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Erin E. MulvihilliD· 2 shared Morgan D. FullertoniD· 2 shared Aaron Reyes· 1 shared Andrew C. Clément· 1 shared Andrew R. PepperiD· 1 shared Antonio A. HansoniD· 1 shared Cassandra A.A. LocatelliiD· 1 shared Charbel Y Karam· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPhysiology

Erin E. MulvihillORCID

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2 papers

Recent·Most cited

Casp1 and Ripk3 are required for homeostatic insulin secretion in mice

Madison D. Girouard, Conor O’Dwyer, Cassandra A.A. Locatelli, Myriam P Hoyeck, Evgenia Fadzeyeva, Tyler K.T. Smith, Rui Yan Gao, Tanvi Ahluwalia, Sophia M. Perrakis, Andrew C. Clément, Antonio A. Hanson, Peyman Ghorbani, Lili Grieco-St-Pierre, Jianfan Nie, Mariam Hakoum, , Morgan D. Fullerton

This study shows that deleting both Casp1 and Ripk3 in mice improves glucose-stimulated insulin secretion, independent of cell death or inflammation.

bioRxiv · Sep 4, 2026 · PreprintPhysiology

OPA1 mediates cardiac function and metabolism: in silico and in vivo evidence

Claire Fong-McMaster, Serena M. Pulente, Luke S Kennedy, Tyler K.T. Smith, Stephanie Myers, Michel N Kanaan, Charbel Y Karam, Matthew Cope, Michelle M. Levesque, Ella McIlroy, Ilka Lorenzen‐Schmidt, Craig J. Goergen, Morgan D. Fullerton, Miroslava Čuperlović‐Culf, Erin E. Mulvihill, Mary‐Ellen Harper

The paper investigates OPA1's role in cardiac function and metabolism using in silico and in vivo approaches, finding that OPA1 overexpression improves cardiac function and maintains metabolic markers in a mouse model.

BMC Cardiovascular Disorders · Dec 9, 2025Peer-reviewedBiochemistry